Genetic modification of pigs as organ donors for xenotransplantation
نویسندگان
چکیده
منابع مشابه
Genetically Modified Pigs as Organ Donors for Xenotransplantation
The growing shortage of available organs is a major problem in transplantology. Thus, new and alternative sources of organs need to be found. One promising solution could be xenotransplantation, i.e., the use of animal cells, tissues and organs. The domestic pig is the optimum donor for such transplants. However, xenogeneic transplantation from pigs to humans involves high immune incompatibilit...
متن کاملScreening Donors for Xenotransplantation
Xenotransplantation is a potential solution to the current donor shortage for solid organ transplantation. The transmission of infectious agents from donor organs or bone marrow to the recipient is a well-recognized phenomenon following allotransplantation. Thus the prospect of xenotransplantation raises the issue of xenozoonoses-i.e., the transmission of animal infections to the human host. An...
متن کاملNonhuman primates as organ donors?
Baboons and pigs are potential source animals for human xenotransplantation. For practical reasons, baboons have been proposed by only a handful of US surgeons to demonstrate “proof of concept”. The Loma Linda paediatric heart transplant performed by Leonard Bailey in 1986 received a lot of negative publicity because of ethical concerns about “experimenting” on a newborn baby. Nevertheless, fur...
متن کاملModifying the Glycome in Pigs for Xenotransplantation.
I of glycosyltransferase genes during human evolution is a fundamental cause of differential glycosylation in humans and pigs, resulting in the presence of carbohydrate structures on pig cells that are recognized by natural (preexisting) human antibodies. αGal, the first of these epitopes to be identified, is synthesized by α1,3galactosyltransferase, encoded by theGGTA1 gene. The crucial import...
متن کاملMinors as living solid-organ donors.
In the past half-century, solid-organ transplantation has become standard treatment for a variety of diseases in children and adults. The major limitation for all transplantation is the availability of donors, and the gap between demand and supply continues to grow despite the increase in living donors. Although rare, children do serve as living donors, and these donations raise serious ethical...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Reproduction and Development
سال: 2009
ISSN: 1040-452X
DOI: 10.1002/mrd.21127